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Clostridium difficile toxin:

This test detects the presence of Clostridium difficile toxin A and B in a fresh or frozen stool sample. C. difficile is a bacterium that is present as part of the normal bacterial flora in the gastrointestinal tract of up to 65% of healthy infants and 3% of healthy adults.

Sometimes, when broad-spectrum Antibiotic are used to treat infections, the balance of the normal flora in the colon can be disrupted. Bacteria that are susceptible to the antibiotic will be eliminated from the GI tract and C.

difficile that are resistant to the antibiotic will remain or new strains of C. difficile may be acquired. The C. difficile may produce two toxins - toxin A and toxin B. The combination of overgrowth of C.

difficile and toxin production can damage the lining of the colon and lead to severe inflammation of the colon and prolonged dirrhea. Dead tissue, fibrin, and numerous white blood cells can form a pseudomembrane over the inflamed bowel, which is referred to as pseudomembranous colitis.

هذا الاختبار يكشف عن وجود المادة السامة الجرثومية المتواجدة فى الجهاز الهضمى ويستخدم لذلك عينة براز وتوجد هذه المادة بنسبة 65% فى الرضع و3 % فى البالغين الاصحاء

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