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Alzheimer biomarkers (Tau/Aß42):

Amyloid beta 42 is a peptide that can undergo increased production resulting in a collection of senil plaques in the brain. Tau is a structural protein of the brain that, when changed chemically (becomes saturated with phosphorus groups, P-tau), can create neuro fibrillary tangles, twisted protein fragments that develop in neurons that disrupt their ability to transport signals.

These tangles in conjunction with the plaques are considered to be the main diagnostic features of alzheimer`s disease at autopsy. The measurement of tau and Aß42 in CSF is being evaluated for potential roles in the diagnosis and monitoring of AD. It has been shown that a decrease in Aß42 with elevated tau or P-tau levels may predict the onset of AD.

The test used to

differentiate between alzheimer`s disease and other forms of early-onset dementia

the way of sample obtaining

A sample of cerebrospinal fluid collected using a spinal tap

Aß42

هو البروتين الهيكلى فى المخ وهو يعمل على تخليق التشابكات العصبية وهذه التشابكات هى الكاشف الرئيسى لمرض الزهيمر

يستخدم هذا الاختبار فى
التفريق بين مرض الزهايمر ومرض ظهور الخرف المبكر

طريقة الحصول على عينة
جمع عينة من السائل الشوكي باستخدام صنبو

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