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Fetal fibronectin (fFN):

Fetal fibronectin (fFN) is a glycoprotein that can be used to help predict the short term risk of premature delivery. fFN is produced at the boundary between the amnionic sac (which surrounds the baby) and the lining of the mother's uterus (the decidua) in an area called the uteroplacental (or choriodecidual) junction.

Fetal fibronectin is largely confined to this junction and is thought to help maintain the integrity of the boundary. fFN is normally detectable in cervicovaginal fluid during early pregnancy, and in a normal pregnancy it is no longer detectable after 24 weeks. However, it reappears and is again detectable after about 36 weeks

A normal pregnancy is 40 weeks with a woman going into labor between 37 and 42 weeks. Finding fFN in cervicovaginal fluids after 36 weeks is not unusual as it is often released by the body as it gets ready for childbirth. The elevated fFN found in vaginal fluids early in pregnancy may simply reflect the normal growth and establishment of tissues at the uteroplacental junction with levels falling when this phase is complete.

What is known is that fFN should not be detectible between 22 and 35 weeks of pregnancy. Elevated levels during this period reflect a disturbance at the uteroplacental junction and have been associated with an increased risk of preterm labor and delivery.

The sample

A cervical or vaginal fluid sample

هو احد البروتينات الكربوهيدراتية ويستخدم فى معرفة حدوث ولادة مبكرة وهذا البروتين ينشا بين كيس الجنين والرحم اثناء الحمل
ويمكن الكشف عنه فى الاسبوع ال36 عن طريق السوائل المهبلية
وهذا السائل يؤخذ من عنق الرحم عن طريق المسح بالسواب

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