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anti-cyclic citrullinated peptide antibody (anti-CCP):

The cyclic citrullinated peptide antibody (CCP) test is a relatively new assay that detects the presence of citrulline antibodies in the blood. These auto antibodies are proteins produced by the immune system in response to a perceived threat from citrulline.

An unusual amino acid, citrulline is produced when the amino acid arginine is altered. There is speculation that the conversion of arginine to citrulline may play a role in the autoimmune inflammatory process seen in the joints of those with rheumatoid arthritis.

Rheumatoid arthritis is a chronic systemic autoimmune disease that causes inflammation, pain, stiffness, and destructive changes in the hands, feet, and other joints throughout the body

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